Food allergy molecule discovered

**SnoWhite_queeN** · 05-26-2008, 11:00 AM

molecule which may protect against food allergy has been identified.

Interleukin-12 has been shown to be "missing" in mice which were bred to be allergic to peanuts.
The results published in the Journal of Allergy and Clinical Immunology suggest that the molecule normally stops allergies to food developing.
The Institute of Food Research scientists said the findings offered a potential target for the prevention or treatment of food allergies. In people who suffer from a food allergy the immune system responds to a food protein as if it was harmful by producing antibodies.

In the most severe cases individuals can suffer life-threatening reactions including anaphylactic shock.
One of the most well-known food allergies is to peanuts. This problem is becoming increasingly common affecting one in 70 schoolchildren.
There is currently no way to treat food allergy and the only way for sufferers to manage the problem is to avoid certain foods and make sure they have injectable adrenaline at hand.

Over-stimulation
Dr Claudio Nicoletti and colleagues had already done research which showed that special types of white blood cells called dendritic cells are important in helping the immune system decide on how to respond to foreign molecules.
They found that in allergic mice the dendritic cells are much longer lasting than normal which over-stimulates the immune system.
In the latest study he compared the activity of dendritic cells in the gut and in the spleen of allergic and allergy-resistant mice.
He found that in the gut of susceptible mice dendritic cells have stopped producing interleukin-12.
Dr Nicoletti said delivering an allergen such as peanut alongside the interleukin-12 molecule. may help to bring allergic reactions back under control.
He is doing a further study to test this theory in mice.
"A food protein can be perfectly harmless to one person and lethal to another" he said.
"We have identified the missing molecule that normally keeps immune responses under control and appropriate."
Dr Nicoletti is also working with researchers in Ireland to identify whether similar characteristics can be found in human dendritic cells.
Preliminary findings suggest the dendritic cells in individuals with a food allergy are also longer lasting.
David Reading director of the Anaphylaxis Campaign said: "Food allergy can place an extremely heavy burden on the families affected. "We welcome this research and look forward to further developments."

05-26-2008, 11:00 AM	#1 (permalink)
SnoWhite_queeN Co Administrator	Food allergy molecule discovered *molecule which may protect against food allergy has been identified.* Interleukin-12 has been shown to be "missing" in mice which were bred to be allergic to peanuts. The results published in the Journal of Allergy and Clinical Immunology suggest that the molecule normally stops allergies to food developing. The Institute of Food Research scientists said the findings offered a potential target for the prevention or treatment of food allergies. In people who suffer from a food allergy the immune system responds to a food protein as if it was harmful by producing antibodies. In the most severe cases individuals can suffer life-threatening reactions including anaphylactic shock. One of the most well-known food allergies is to peanuts. This problem is becoming increasingly common affecting one in 70 schoolchildren. There is currently no way to treat food allergy and the only way for sufferers to manage the problem is to avoid certain foods and make sure they have injectable adrenaline at hand. Over-stimulation Dr Claudio Nicoletti and colleagues had already done research which showed that special types of white blood cells called dendritic cells are important in helping the immune system decide on how to respond to foreign molecules. They found that in allergic mice the dendritic cells are much longer lasting than normal which over-stimulates the immune system. In the latest study he compared the activity of dendritic cells in the gut and in the spleen of allergic and allergy-resistant mice. He found that in the gut of susceptible mice dendritic cells have stopped producing interleukin-12. Dr Nicoletti said delivering an allergen such as peanut alongside the interleukin-12 molecule. may help to bring allergic reactions back under control. He is doing a further study to test this theory in mice. "A food protein can be perfectly harmless to one person and lethal to another" he said. "We have identified the missing molecule that normally keeps immune responses under control and appropriate." Dr Nicoletti is also working with researchers in Ireland to identify whether similar characteristics can be found in human dendritic cells. Preliminary findings suggest the dendritic cells in individuals with a food allergy are also longer lasting. David Reading director of the Anaphylaxis Campaign said: "Food allergy can place an extremely heavy burden on the families affected. "We welcome this research and look forward to further developments."

Seçenekler
Yazdırılabilir şekli göster Sayfayı E-Mail olarak gönder
Stil
Normal Hybrid-Şeklinde gösterime geç Ağaç şeklinde gösterime geç

Benzer Konular
Konu	Konuyu Başlatan	UslanmaM	Cevaplar	Son Mesaj
Hundreds Of San Diego Area Residents Take Strides For Food Allergy Research	USLANMAM	Latest Health News	0	08-15-2007 10:30 AM
Pet Food Recall Expanded: Melamine Found In Blue Buffalo Kitten Food And Corn Gluten	USLANMAM	Latest Health News	0	04-21-2007 06:10 PM
Landmark Food Allergy Law Enacted In New Jersey	USLANMAM	Latest Health News	0	03-21-2007 08:00 AM
World Food Programme Lauds German Move To Boost Aid For Afghanistan Where More Food A	USLANMAM	Latest Health News	0	03-02-2007 04:40 PM
Hungry Best Served By Combination Of Food And Cash Transfers, Says World Food Program	USLANMAM	Latest Health News	0	03-01-2007 05:30 PM

Konuyu Toplam 1 Üye okuyor. (0 Kayıtlı üye ve 1 Misafir)